Okay, I'm probably going to get hate for this since this is the most popular ship in the Soul Eater fandom, but I strongly stand against it. Here's some reasons why I think it wouldn't work out.

Reason 1 - It's far too cliche
Honestly, them ending up is too predictable. I think the story is far better off at leaving them as friends. There's too many shounen anime and manga that have the main girl and guy end up together in the end and having them not be together is something different and I'd amor to just leave it at that.

Reason 2 - Their personalities clash too much for romance
Although they...

It is important to watch Soul Eater Not! Like wanna know how Sid became a Zombie? o how Liz and Patty meet Kid. Watch Soul Eater Not! It explains that. Not gonna spoil anything. I know it's a spin off series, but it takes place before the original SE Series. I say it is worth watching. It explains some character back story that the original series didn't explain much of. Like remember how an episode where Soul scared Maka cause of explaining how Sid died. Well.... Will just leave it to Soul Eater Not to explain back stories the original didn't explain. Also I believe it was in Episode 3 or...