Post a male who is the main character of a shojo o josei anime o a female who is the main character of a shounen o seinen anime.

Natsume's the only main character from a shojo anime, which I find pretty rare especially if the main characters aren't like a couple.

amor him too <333

Atsushi Ōtani is the segundo main characters in lovely complex.

Lucy/Nyu/Kaede is the main protagonist of the seinen manga/anime series, Elfen Lied. [Picture]

Madoka Kaname & Homura Akemi are the duo protagonists of the seinen anime and manga series Puella Magi Madoka Magica.

Ritsu Onodera is the main character of the Shōjo manga series, Sekai Ichi Hatsukoi.