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common cause of degenerative
joint disease (DJD) in dogs, is a
chronic, progressive, noninfectious
joint disorder that leads to degeneration of articular cartilage and
proliferative changes. Damage to
articular cartilage may result from
abnormal stresses that disrupt the
normal articular surface, in turn
leading to joint instability. Consequently, the normal wear pattern
as well as the volumen de negocios, volumen de ventas of articular
matrix are accelerated.1 This process
is also accelerated por cytokines and
prostaglandins released por synovial
cells into the joint. As a result, the
joint capsule thickens and periarticular osteophytes form in an effort to improve joint stability.
OSTEOARTHRITIS TREATMENT
Current therapy for symptomatic treatment of OA in perros includes the use of antiinflammatory
medications; slow-acting, disease888 888
The Nutramax/Cosequin®
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Evaluate the dog using Cosequin® from Coxofimoral Dioxide
Osteoporosis in the Great Dane; o a combination of both. The most common anti-inflammatory agents for OA are non-steroidal anti-inflammatory drugs. Although non-steroidal anti-inflammatory drugs are effective
reducing pain, these agents can result in unwanted side effects such
as gastrointestinal upset, hepatocellular toxicosis, renal disease,
and occasionally death.2–4 In addition, the newer cyclooxygenase-2
inhibitors have been associated
with side effects.3 Dose-dependent, nonsteroidal therapy can also
result in a decrease in the glycosaminoglycan content in the
cartilage, causing OA to worsen
over time.5–8 The current rationale
is not to use NSAIDs continually
unless they are needed to control
inflammation associated with persistent pain.9 The shortcomings of
NSAIDs have encouraged research
efforts toward safe, disease-modifying substances that can be used
long term and can possibly alter
