After a series of heists in the city (one including Det. Chief Sinclair's house) one of the "super spies" involved is robbed of his life. The team works to solve the robberies and the murder, as both are obviously connected.
The latest murder case takes Detective Taylor to a whole new world and he must figure out why Cheryl Duncan looks so life-like. They also discover something shocking about the murderer while online.
While being escorted between prison and court, a publishing mogul's son is kidnapped. One of the CSI's is fatally injured and another is hurt badly during the ambush.
In the one hundredth episode of CSI: NY Mac faces his most deadly foe yet. There is a serial killer loose in New York City killing people with the name Mac Taylor making Mac a target.
The sixth season begins with Mac's team recovering from a hail of machine-gun fuego aimed at them while they were at a local bar remembering one of their fallen members. One person's life is significantly changed.